DNA Screenings: A Thing of the Future is hereDNA Screenings

Knowing your family's genetic history may someday save your life or that of someone you love. Based on genetic technology, a unique DNA analysis can be made for an individual, stating all the deficiencies and potential genetic disorders, thus, preparing one to fight the signs and symptoms of diseases. What better gift can a loved one leave behind?

The vast spectrum of DNA can give us insight on the value it can play in our lives. These startling revelations came into light during Human Genome Project. DNA research and Human Genome Mapping has allowed scientists to discover about how one’s unique DNA influences one’s health. Based on these studies, a simple DNA test at home lets a person know what exact supplements one’s body needs and how much. This revolutionary breakthrough has lead to the designing of vitamin supplements based on one’s unique DNA.

An individual’s DNA holds the secret to enhanced state of wellbeing as well as diminished state of wellbeing. Even a slight difference in this genetic code leads to a living being’s vulnerability to diseases. vitamin supplements are made after DNA analysis, meeting an individual’s needs and requirements to keep him or her healthy. Total wellbeing can be attained through DNA customized supplements as they contain the essential nutrients which help to regain the lost health and also slows the aging process. As these supplements are tailor made, therefore, each supplement is based on an individual’s own requirements, augmenting the complete well being

QuikChIP Chromatin Immunoprecipitation Kits

IMGENEX QuikChIP Certified Antibodies The Basics...
The principle of the ChIP assay is simple: selective enrichment of a chromatin fraction containing a specific target. However, the process can be technically challenging. It is with these challenges in mind that IMGENEX developed the QuikChIP Kit for chromatin immunoprecipitation. QuikChIP includes optimized ready-to-use buffers and inhibitory reagents, as well as a comprehensive technical manual.

* Quick & simple
* Optimized ready-to-use buffers & protocol
* Useful for Histone and non-histone proteins

Reagents for 25 ChIP assays and sheared Chromatin preparations


QuikChIP Certified Antibodies

IMGENEX offers a growing number of antibodies that have been validated for use in ChIP assays and we are continually testing and validating new products for use in ChIP. Below is a list of our currently available QuikChIP Certified Antibodies. Be sure to check our website often as we are releasing new antibodies every week!

Sheared Chromatin

IMGENEX QuikChIP™ Sheared Chromatin is ready-to-use, sheared, cross-linked chromatin prepared from mammalian cell extracts. This novel product enables researchers to carry out ChIP assays in the absence of cell culture facilities or sonication equipment. It is also useful as a sheared, cross-linked chromatin positive control, alongside your own cell extracts.

Conditions for cell culture, DNA-protein cross-linking, and the sonication shearing process have been optimized for each human and mouse cell type.

IMGENEX has now p73 phosphospecific antibody

The p53 family member, p73, also known as tumor protein 73 (TP73) has been recently identified as a structural and functional homolog of the tumor suppressor protein p53. In accordance with its structural similarity, p73 functions in a manner analogous to p53 by inducing tumor cell apoptosis and participating in the cell cycle checkpoint control through transactivating an overlapping set of p53/p73-target genes. Under these conditions p73 is tyrosine-phosphorylated by c-Abl, a prerequisite modification for p73 to elicit cell death in fibroblasts. Increasing knowledge of its function, however, has cast doubts on its role. Like p53, the protein contains different isoforms with distinct and sometimes opposite functions.
Like other members of the p53 family, p73 protein share the same modular organization consisting of an N-terminal transactivation domain, central sequence-specific DNA-binding domain, and a C-terminal tetramerization domain. However, the p73 gene encodes multiple isoforms varying in their N and C termini. In some cases, the use of a cryptic promoter generates isoforms lacking the transactivation domain located in the N terminus of p73 (deltaNp73 alpha and deltaNp73 beta). The p73 gene also generates several forms with varying C-terminal extensions,TAp73 (p73 alpha, beta, gamma, delta and epsilon). These splicing variants are expressed differently in normal human tissues and cell lines. The p73 gene has been mapped to human chromosome 1p36, a region that is frequently deleted in variety of human cancers including neuroblastoma, colon cancer, and breast cancer.
The precise functions of p73 proteins in the organism and the signaling pathways that regulate their activity are still not well established. An interesting recent report shows that p73 is required for p53-dependent apoptosis induced by DNA damage as well as p53-independent apoptosis. These observations and the fact that p73 expression is affected in certain tumors suggest that p73 may function as a tumor suppressor gene. However, p73 deficient mice are not particularly prone to cancer, and only rarely have mutation or inactivation of p73 expression been found in human tumors. On the contrary the deltaNp73 isoforms have oncogenic potential and act in a dominant negative manner against TAp73 as well as p53. The Delta N isoforms of p73 can also protect neurons from apoptosis. Besides like p53, p73 may also play a role in developmental processes. Several lines of evidence show that p73 may play a role in nervous system and immune system development, thus implicating the role of p73 in cellular differentiation.